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2018 Price of Thalidomide
Thalomid 50 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Thalidomide volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Thalidomide
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action.
Thalidomide mechanism of action
In patients with erythema nodosum leprosum (ENL) the mechanism of action is not fully understood. Available data from in vitro studies and preliminary clinical trials suggest that the immunologic effects of this compound can vary substantially under different conditions, but may be related to suppression of excessive tumor necrosis factor-alpha (TNF-a) production and down-modulation of selected cell surface adhesion molecules involved in leukocyte migration. For example, administration of thalidomide has been reported to decrease circulating levels of TNF-a in patients with ENL, however, it has also been shown to increase plasma TNF-a levels in HIV-seropositive patients. As a cancer treatment, the drug may act as a VEGF inhibitor.
Dosage forms of Thalidomide
|Capsule, hard||Oral use||50 mg|
Humans and other mammals
Indication of Thalidomide
For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
Toxicity of Thalidomide
The R-configuration and the S-configuration are more toxic individually than the racemic mixture. The LD sub 50 /sub could not be established in mice for racemic thalidomide, whereas LD sub 50 /sub values for the R and S configurations are reported to be 0.4 to 0.7 g/kg and 0.5 to 1.5 g/kg, respectively.
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