Save up -80% on Theophylline
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Price of Theophylline
Theo-24 200 mg capsule sa
* price without discount in nearest pharmacy. Price may vary.
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Theophylline volume of distribution
* 0.3 to 0.7 L/kg
What is Theophylline
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Theophylline mechanism of action
Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
Dosage forms of Theophylline
|Tablet (extended-release)||oral||100 mg|
|Tablet (extended-release)||oral||200 mg|
|Tablet (extended-release)||oral||300 mg|
Humans and other mammals
Indication of Theophylline
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Toxicity of Theophylline
Symptoms of overdose include seizures, arrhythmias, and GI effects.
Disclaimer: before buying a Theophylline on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.