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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Thiotepa

Thiotepa 15 mg vial



* price without discount in nearest pharmacy. Price may vary.

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Thiotepa volume of distribution

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What is Thiotepa

N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N’,N”- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.

Thiotepa mechanism of action

The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically.

Dosage forms of Thiotepa

Powder for solutionoral; rectal; surgical; vaginal15 mg
Injection, powder, lyophilized, for solutionintracavitary; intravenous; intravesical15 mg/1.5mL
Powder for solutionintracavitary; intravesicular; intravenous15 mg
Prescription Generics


International Brands

Thio Tepa Inj 15mg/vial




Lederle Cyanamid Canada Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Thiotepa

ThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.

Toxicity of Thiotepa

RX24 Drugs Disclaimer: before buying a Thiotepa on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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