Save up -80% on Thiotepa
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2018 Price of Thiotepa
Thiotepa 15 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Thiotepa volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Thiotepa
N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N’,N”- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Thiotepa mechanism of action
The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically.
Dosage forms of Thiotepa
|Powder for solution||oral; rectal; surgical; vaginal||15 mg|
|Injection, powder, lyophilized, for solution||intracavitary; intravenous; intravesical||15 mg/1.5mL|
|Powder for solution||intracavitary; intravesicular; intravenous||15 mg|
Thio Tepa Inj 15mg/vial
Lederle Cyanamid Canada Inc.
Humans and other mammals
Indication of Thiotepa
ThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.
Toxicity of Thiotepa
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