Save up -80% on Thyrotropin Alfa
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Price of Thyrotropin Alfa
Thyrogen 1.1 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Thyrotropin Alfa volume of distribution
What is Thyrotropin Alfa
Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Thyrotropin Alfa mechanism of action
Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging.
Dosage forms of Thyrotropin Alfa
|Injection, powder, for solution||intramuscular||.9 mg/mL|
|Powder for solution||intramuscular||0.9 mg|
Thyroid stimulating hormone
Genzyme Canada A Division Of Sanofi Aventis Canada Inc
Humans and other mammals
Indication of Thyrotropin Alfa
For detection of residueal or recurrent thyroid cancer
Toxicity of Thyrotropin Alfa
No difference in efficacy and toxicity between adult and geriatric patients. No studies in lactating women, pregnant women and pediatrics. Cautionary administration is advised.
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