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Price of Timolol
Apo-Timop 0.25 % Solution
* price without discount in nearest pharmacy. Price may vary.
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Timolol volume of distribution
What is Timolol
A beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor. (PubChem)
Timolol mechanism of action
Like propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.
Dosage forms of Timolol
|Eye drops, suspension||Ocular use|
|Solution/ drops||ophthalmic||2.56 mg/mL|
Actavis Pharma Company
Humans and other mammals
Indication of Timolol
In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
Toxicity of Timolol
LD sub 50 /sub =1190 mg/kg (oral, mice), LD sub 50 /sub =900 mg/kg (oral, rat). Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block.
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