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Price of Tinidazole
Tindamax 250 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Tinidazole volume of distribution
* 50 L
What is Tinidazole
A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections. (PubChem)
Tinidazole mechanism of action
Tinidazole is a prodrug and antiprotozoal agent. The nitro group of tinidazole is reduced in iTrichomonas/i by a ferredoxin-mediated electron transport system. The free nitro radical generated as a result of this reduction is believed to be responsible for the antiprotozoal activity. It is suggested that the toxic free radicals covalently bind to DNA, causing DNA damage and leading to cell death. The mechanism by which tinidazole exhibits activity against iGiardia/i and iEntamoeba/i species is not known, though it is probably similar.
Dosage forms of Tinidazole
|Tablet, film coated||oral||250 mg/1|
|Tablet, film coated||oral||500 mg/1|
Mission Pharmacal Company
Trichomonas vaginalis, Giardia duodenalis, and Entamoeba histolytica
Indication of Tinidazole
For the treatment of trichomoniasis caused by iT. vaginalis/i in both female and male patients. Also for the treatment of giardiasis caused by iG. duodenalis/i in both adults and pediatric patients older than three years of age and for the treatment of intestinal amebiasis and amebic liver abscess caused by iE. histolytica/i in both adults and pediatric patients older than three years of age.
Toxicity of Tinidazole
There are no reported overdoses with tinidazole in humans. In acute studies with mice and rats, the LD 50 for mice was generally 3,600 mg/kg for oral administration and was 2,300 mg/kg for intraperitoneal administration. In rats, the LD 50 was 2,000 mg/kg for both oral and intraperitoneal administration.
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