Save up -80% on Tioconazole
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2018 Price of Tioconazole
Tioconazole 1 6.5% ointment
* price without discount in nearest pharmacy. Price may vary.
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Tioconazole volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tioconazole
Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete’s foot, and tinea versicolor or “sun fungus”. Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
Tioconazole mechanism of action
Tioconazole interacts with 14-alpha; demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
Dosage forms of Tioconazole
|Ointment; cream||topical; vaginal|
|Suppository; cream||topical; vaginal|
Careone Tioconazole 1
American Sales Company
Yeast and other fungi
Indication of Tioconazole
For the local treatment of vulvovaginal candidiasis (moniliasis).
Toxicity of Tioconazole
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
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