Save up -80% on Tioguanine

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Tioguanine

Tabloid tablet



* price without discount in nearest pharmacy. Price may vary.

Claim your free Tioguanine coupon

We offer free Tioguanine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Tioguanine every time. What are you waiting for? Claim your prescription drug card now!

Get your Prescription
It’s safe and free
Buy drugs in pharmacy
Save money each time

Tioguanine volume of distribution

About RX24Drugs

Discount Cards 16,000+

Clients Benefit 29%

Total savings $4,735,080

What is Tioguanine

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

Tioguanine mechanism of action

Thioguanine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to 6-thioguanilyic acid (TGMP), which reaches high intracellular concentrations at therapeutic doses. TGMP interferes with the synthesis of guanine nucleotides by its inhibition of purine biosynthesis by pseudofeedback inhibition of glutamine-5-phosphoribosylpyrophosphate amidotransferase, the first enzyme unique to the de novo pathway of purine ribonucleotide synthesis. TGMP also inhibits the conversion of inosinic acid (IMP) to xanthylic acid (XMP) by competition for the enzyme IMP dehydrogenase. Thioguanine nucleotides are incorporated into both the DNA and the RNA by phosphodiester linkages, and some studies have shown that incorporation of such false bases contributes to the cytotoxicity of thioguanine. Its tumor inhibitory properties may be due to one or more of its effects on feedback inhibition of de novo purine synthesis; inhibition of purine nucleotide interconversions; or incorporation into the DNA and RNA. The overall result of its action is a sequential blockade of the utilization and synthesis of the purine nucleotides.

Dosage forms of Tioguanine

Form Route Strength
Tablet oral 40 mg
Tablet oral 40 mg/1
Prescription Generics


International Brands



2-Amino 6mp 2-Amino-1,7-dihydro-6H-purine-6-thione


Aspen Pharma Trading Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Tioguanine

For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.

Toxicity of Tioguanine

Oral, mouse: LD sub 50 /sub = 160 mg/kg. Symptoms of overdose include nausea, vomiting, malaise, hypotension, and diaphoresis.

RX24 Drugs Disclaimer: before buying a Tioguanine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

Get lower price on Tioguanine now!

Leave a Review