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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tioguanine

Tabloid tablet

$9.44tablet
price without discount in nearest pharmacy. Price may vary.

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Tioguanine volume of distribution

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Tioguanine

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

Tioguanine mechanism of action

Thioguanine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to 6-thioguanilyic acid (TGMP), which reaches high intracellular concentrations at therapeutic doses. TGMP interferes with the synthesis of guanine nucleotides by its inhibition of purine biosynthesis by pseudofeedback inhibition of glutamine-5-phosphoribosylpyrophosphate amidotransferase, the first enzyme unique to the de novo pathway of purine ribonucleotide synthesis. TGMP also inhibits the conversion of inosinic acid (IMP) to xanthylic acid (XMP) by competition for the enzyme IMP dehydrogenase. Thioguanine nucleotides are incorporated into both the DNA and the RNA by phosphodiester linkages, and some studies have shown that incorporation of such false bases contributes to the cytotoxicity of thioguanine. Its tumor inhibitory properties may be due to one or more of its effects on feedback inhibition of de novo purine synthesis; inhibition of purine nucleotide interconversions; or incorporation into the DNA and RNA. The overall result of its action is a sequential blockade of the utilization and synthesis of the purine nucleotides.

Dosage forms of Tioguanine

FormRouteStrength
Tabletoral40 mg
Tabletoral40 mg/1

Prescription Generics

false

International Brands

Lanvis

Synonyms

2-Amino 6mp 2-Amino-1,7-dihydro-6H-purine-6-thione

Manufacturers

Aspen Pharma Trading Limited

CAS number

154-42-7

UNII

WIX31ZPX66

State

solid

Affected organisms

Humans and other mammals

Indication of Tioguanine

For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.

Toxicity of Tioguanine

Oral, mouse: LD sub 50 /sub = 160 mg/kg. Symptoms of overdose include nausea, vomiting, malaise, hypotension, and diaphoresis.

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