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Price of Tiotropium
Spiriva 18 mcg Capsule
* price without discount in nearest pharmacy. Price may vary.
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Tiotropium volume of distribution
* 32 L/kg
What is Tiotropium
Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.
Tiotropium mechanism of action
Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.
Dosage forms of Tiotropium
|Capsule||oral; respiratory (inhalation)||18 ug/1|
Boehringer Ingelheim (Canada) Ltd Ltee
Humans and other mammals
Indication of Tiotropium
Used in the management of chronic obstructive pulmonary disease (COPD).
Toxicity of Tiotropium
No mortality was observed at inhalation tiotropium doses up to 32.4 mg/kg in mice, 267.7 mg/kg in rats, and 0.6 mg/kg in dogs. These doses correspond to 7,300, 120,000, and 850 times the recommended human daily dose on a mg/m2 basis, respectively.
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