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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Spiriva

$443.21 handihaler (30 capsules)/18 mcg
Price with discount in nearest pharmacy. Price may vary.

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Tiotropium volume of distribution

Tiotropium at a level of 72% to plasma proteins shows a volume of distribution of 32 l/kg. At steady state, tiotropium plasma levels in COPD patients at peak were 17–19 pg/ml when measured 5 min after inhalation of an 18-μg dose, and steady state trough plasma concentrations were 3–4 pg/ml.

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What is Tiotropium

Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.

Tiotropium mechanism of action

Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.

Dosage forms of Tiotropium

Spiriva Handihaler18mcg30 Capsule Inhaler$44.70
Spiriva Handihaler18mcg90 Capsule Inhaler$77.50
Spiriva Respimat2.5mcg60ds Respimat Inhaler$120.00
Spiriva Respimat2.5mcg180ds Respimat Inhaler$340.00
Tiotropium bromide18mcg90 Rotacaps$37.10
Stiolto Respimat2.5mcg/2.5mcg60puffs Respimat Inhaler$190.00
Stiolto Respimat2.5mcg/2.5mcg120puffs Respimat Inhaler$370.00

Prescription Generics


International Brands

Inspiolto Respimat



Boehringer Ingelheim (Canada) Ltd Ltee

CAS number






Affected organisms

Humans and other mammals

Indication of Tiotropium

Used in the management of chronic obstructive pulmonary disease (COPD).

Toxicity of Tiotropium

No mortality was observed at inhalation tiotropium doses up to 32.4 mg/kg in mice, 267.7 mg/kg in rats, and 0.6 mg/kg in dogs. These doses correspond to 7,300, 120,000, and 850 times the recommended human daily dose on a mg/m2 basis, respectively.

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What is Spiriva?

Siriva contains tiotropium bromide – a substance with a prolonged m-anticholinergic action. It has an affinity for M1-M5 muscarinic receptors. As a result of receptor inhibition, relaxation of the smooth muscles of the respiratory tract is observed. Bronchodilatory effect dose-dependent, long-lasting (about a day).

During inhalation, a selective action in the form of bronchodilation is noted, systemic reactions are rarely observed. The drug increases FEV1, FZHEL. Cases of development of tolerance were not observed. The use of the drug Spiriva has a positive effect on the quality of life of patients with COPD, reduces the number of hospitalizations.