Save up -80% on Tipranavir
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Aptivus
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We offer free Tipranavir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Tipranavir every time. What are you waiting for? Claim your prescription drug card now!
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Tipranavir volume of distribution
It has a volume of distribution of 8-10 L when boosted with 200mg of ritonavir. Tipranavir reaches an average Cmax of 77.6 ± 16.6 µM (males) and 94.8 ± 22.8 µM (females) ~ 3 hours after dosing.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tipranavir
Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. It is administered with ritonavir in combination therapy to treat HIV infections.
Tipranavir mechanism of action
Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. Two mechanisms are suggested in regards to the potency of tipranavir: 1. Tipravanir may bind to the active site of the protease enzyme with fewer hydrogen bonds than peptidic protease inhibitors, which results in increased flexibility, allowing it to fit into the active site of the enzyme in viruses that have become resistance to other protease inhibitors. This also enables tipranavir to adjust to amino acid substitutions at the active site. 2. Tipranavir’s strong hydrogen bonding interaction with the amide backbone of the protease active site Asp30 may lead to its activity against resistant viruses.
Dosage forms of Tipranavir
|Capsule, liquid filled||oral||250 mg/1|
Boehringer Ingelheim (Canada) Ltd Ltee
Human Immunodeficiency Virus
Indication of Tipranavir
For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors.
Toxicity of Tipranavir
Oral LD sub 50 /sub in rat is over 5,000 mg/kg. Side effects include thirst and hunger, unexplained weight loss, increased urination, fatigue, and dry, itchy skin.
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