Save up -80% on Tipranavir
Note: this is a drug discount program, not an insurance plan.
2018 Price of Tipranavir
Aptivus 100 mg/ml solution
* price without discount in nearest pharmacy. Price may vary.
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Tipranavir volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Tipranavir mechanism of action
Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. Two mechanisms are suggested in regards to the potency of tipranavir: 1. Tipravanir may bind to the active site of the protease enzyme with fewer hydrogen bonds than peptidic protease inhibitors, which results in increased flexibility, allowing it to fit into the active site of the enzyme in viruses that have become resistance to other protease inhibitors. This also enables tipranavir to adjust to amino acid substitutions at the active site. 2. Tipranavir’s strong hydrogen bonding interaction with the amide backbone of the protease active site Asp30 may lead to its activity against resistant viruses.
Dosage forms of Tipranavir
|Capsule, liquid filled||oral||250 mg/1|
Boehringer Ingelheim (Canada) Ltd Ltee
Human Immunodeficiency Virus
Indication of Tipranavir
For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors.
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