Save up -80% on Tipranavir

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tipranavir

Aptivus 100 mg/ml solution

$4.29

ml

* price without discount in nearest pharmacy. Price may vary.

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Tipranavir volume of distribution

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What is Tipranavir

Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. It is administered with ritonavir in combination therapy to treat HIV infections.

Tipranavir mechanism of action

Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. Two mechanisms are suggested in regards to the potency of tipranavir: 1. Tipravanir may bind to the active site of the protease enzyme with fewer hydrogen bonds than peptidic protease inhibitors, which results in increased flexibility, allowing it to fit into the active site of the enzyme in viruses that have become resistance to other protease inhibitors. This also enables tipranavir to adjust to amino acid substitutions at the active site. 2. Tipranavir’s strong hydrogen bonding interaction with the amide backbone of the protease active site Asp30 may lead to its activity against resistant viruses.

Dosage forms of Tipranavir

FormRouteStrength
Capsuleoral250 mg
Capsule, liquid filledoral250 mg/1
Solutionoral100 mg/mL
Prescription Generics

false

International Brands

Aptivus

Synonyms

Manufacturers

Boehringer Ingelheim (Canada) Ltd Ltee

CAS number

174484-41-4

UNII

ZZT404XD09

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Tipranavir

For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors.

Toxicity of Tipranavir

Oral LD sub 50 /sub in rat is over 5,000 mg/kg. Side effects include thirst and hunger, unexplained weight loss, increased urination, fatigue, and dry, itchy skin.

RX24 Drugs Disclaimer: before buying a Tipranavir on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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