Save up -80% on Tizanidine

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zanaflex

$14.0990 tablets/4 mg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Tizanidine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Tizanidine every time. What are you waiting for? Claim your prescription drug card now!

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Tizanidine volume of distribution

Tizanidine is extensively distributed throughout the body with a mean steady-state volume of distribution of 2.4 L/kg (CV = 21%) following intravenous administration in healthy adult volunteers.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Tizanidine

Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.

Tizanidine mechanism of action

Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites.

Dosage forms of Tizanidine

Tabletoral4 mg
Tabletoral2 mg

Prescription Generics


International Brands

Comfort Pac With Tizanidine


5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Tizanidin


Pd Rx Pharmaceuticals, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Tizanidine

For the management of increased muscle tone associated with spasticity

Toxicity of Tizanidine

Transient and asymptomatic elevations in serum ALT greater than 3 times the upper limit of normal occur in ~5% of patients taking tizanidine compared to 0.4% of subjects on placebo. Reports of severe hepatotoxicity, acute liver failure and death have been mentioned in review articles on tizanidine, but few case reports have been published. In these reports, the latency to onset of jaundice has ranged from 2 to 14 weeks and the enzyme elevations have been both cholestatic and hepatocellular. Immunoallergic and autoimmune features have not been mentioned. Recovery was complete after 1 to 2 months.

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