Save up -80% on Tizanidine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Zanaflex
|$14.09||90 tablets/4 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Tizanidine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Tizanidine every time. What are you waiting for? Claim your prescription drug card now!
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Tizanidine volume of distribution
Tizanidine is extensively distributed throughout the body with a mean steady-state volume of distribution of 2.4 L/kg (CV = 21%) following intravenous administration in healthy adult volunteers.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tizanidine
Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
Tizanidine mechanism of action
Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites.
Dosage forms of Tizanidine
Comfort Pac With Tizanidine
Pd Rx Pharmaceuticals, Inc.
Humans and other mammals
Indication of Tizanidine
For the management of increased muscle tone associated with spasticity
Toxicity of Tizanidine
Transient and asymptomatic elevations in serum ALT greater than 3 times the upper limit of normal occur in ~5% of patients taking tizanidine compared to 0.4% of subjects on placebo. Reports of severe hepatotoxicity, acute liver failure and death have been mentioned in review articles on tizanidine, but few case reports have been published. In these reports, the latency to onset of jaundice has ranged from 2 to 14 weeks and the enzyme elevations have been both cholestatic and hepatocellular. Immunoallergic and autoimmune features have not been mentioned. Recovery was complete after 1 to 2 months.
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