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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tobramycin

Pms-Tobramycin 0.3 % Solution

$1.05

ml

* price without discount in nearest pharmacy. Price may vary.

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Tobramycin volume of distribution

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What is Tobramycin

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species.

Tobramycin mechanism of action

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.

Dosage forms of Tobramycin

FormRouteStrength
Solutionrespiratory (inhalation)300 mg/4mL
Solutionrespiratory (inhalation)300 mg/5mL
Liquidintramuscular; intravenous1.2 g
Prescription Generics

false

International Brands

Act Tobramycin Inhalation Solution

Synonyms

3′-Deoxykanamycin b Nebramycin 6

Manufacturers

Actavis Pharma Company

CAS number

32986-56-4

UNII

VZ8RRZ51VK

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Tobramycin

For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.

Toxicity of Tobramycin

LD sub50 /sub=441mg/kg (s.c. in mice)

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