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Price of Tobramycin
Pms-Tobramycin 0.3 % Solution
* price without discount in nearest pharmacy. Price may vary.
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Tobramycin volume of distribution
What is Tobramycin
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species. (PubChem)
Tobramycin mechanism of action
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
Dosage forms of Tobramycin
|Solution||respiratory (inhalation)||300 mg/4mL|
|Solution||respiratory (inhalation)||300 mg/5mL|
|Liquid||intramuscular; intravenous||1.2 g|
Act Tobramycin Inhalation Solution
Actavis Pharma Company
Enteric bacteria and other eubacteria
Indication of Tobramycin
For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
Toxicity of Tobramycin
LD sub50 /sub=441mg/kg (s.c. in mice)
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