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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tolcapone

Tasmar 200 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Tolcapone volume of distribution

* 9 L

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What is Tolcapone

Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson‘s disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. (Wikipedia)

Tolcapone mechanism of action

The precise mechanism of action of tolcapone is unknown, but it is believed to be related to its ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa, resulting in an increase in plasma levodopa concentrations. The inhibition of COMT also causes a reduction in circulating 3-OMD as a result of decreased peripheral metabolism of levodopa. This may lead to an increase distribution of levodopa into the CNS through the reduction of its competitive substrate, 3-OMD, for transport mechanisms. Sustained levodopa concentrations presumably result in more consistent dopaminergic stimulation, resulting in greater reduction in the manifestations of parkinsonian syndrome.

Dosage forms of Tolcapone

Film-coated tabletOral use100 mg
Film-coated tabletOral use200 mg
Tabletoral100 mg
Prescription Generics


International Brands



(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone


Hoffmann La Roche Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Tolcapone

Used as an adjunct to levodopa/carbidopa therapy for the symptomatic treatment of Parkinson’s Disease. This drug is generally reserved for patients with parkinsonian syndrome receiving levodopa/carbidopa who are experiencing symptom fluctuations and are not responding adequately to or are not candidates for other adjunctive therapies.

Toxicity of Tolcapone

LD sub 50 /sub = 1600 mg/kg (Orally in rats)

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