Save up -80% on Tolcapone

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tasmar

$3,528.9930 tablets/100mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Tasmar coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Tolcapone every time. What are you waiting for? Claim your prescription drug card now!

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Tolcapone volume of distribution

The absolute bioavailability of an oral dose was approximately 60%. The volume of distribution was approximately 9 1, and the total clearance was approximately 71.h-l, resulting in a mean plasma half-life of 1.8 h.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Tolcapone

Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson‘s disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. (Wikipedia)

Tolcapone mechanism of action

The precise mechanism of action of tolcapone is unknown, but it is believed to be related to its ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa, resulting in an increase in plasma levodopa concentrations. The inhibition of COMT also causes a reduction in circulating 3-OMD as a result of decreased peripheral metabolism of levodopa. This may lead to an increase distribution of levodopa into the CNS through the reduction of its competitive substrate, 3-OMD, for transport mechanisms. Sustained levodopa concentrations presumably result in more consistent dopaminergic stimulation, resulting in greater reduction in the manifestations of parkinsonian syndrome.

Dosage forms of Tolcapone

DrugDosageQuantityPrice
Tasmar100mg100 Tablet$299.00

Prescription Generics

false

International Brands

Tasmar

Synonyms

(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone

Manufacturers

Hoffmann La Roche Limited

CAS number

134308-13-7

UNII

CIF6334OLY

State

solid

Affected organisms

Humans and other mammals

Indication of Tolcapone

Used as an adjunct to levodopa/carbidopa therapy for the symptomatic treatment of Parkinson’s Disease. This drug is generally reserved for patients with parkinsonian syndrome receiving levodopa/carbidopa who are experiencing symptom fluctuations and are not responding adequately to or are not candidates for other adjunctive therapies.

Toxicity of Tolcapone

LD sub 50 /sub = 1600 mg/kg (Orally in rats)

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