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Price of Tolnaftate
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Tolnaftate volume of distribution
What is Tolnaftate
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete’s foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
Tolnaftate mechanism of action
Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Dosage forms of Tolnaftate
Absorbine Antifungal Powder 1%
m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
W.F. Young, Inc.
Yeast and other fungi
Indication of Tolnaftate
Tolnaftate topical is used to treat skin infections such as athlete’s foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete’s foot.
Toxicity of Tolnaftate
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
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