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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tolvaptan


* price without discount in nearest pharmacy. Price may vary.

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Tolvaptan volume of distribution

Healthy subjects: 3L/kg; slightly higher in heart failure patients.

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What is Tolvaptan

Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.

Tolvaptan mechanism of action

Tolvaptan is a selective and competitive arginine vasopressin receptor 2 antagonist. Vasopressin acts on the V2 receptors found in the walls of the vasculature and luminal membranes of renal collecting ducts. By blocking V2 receptors in the renal collecting ducts, aquaporins do not insert themselves into the walls thus preventing water absorption. This action ultimately results in an increase in urine volume, decrease urine osmolality, and increase electrolyte-free water clearance to reduce intravascular volume and an increase serum sodium levels. Tolvaptan is especially useful for heart failure patients as they have higher serum levels of vasopressin.

Dosage forms of Tolvaptan

Tabletoral15 mg/1
Tabletoral15 mg
Prescription Generics


International Brands





Otsuka Pharmaceutical Co Ltd

CAS number






Affected organisms

Humans and other mammals

Indication of Tolvaptan

Treatment of symptomatic and resistant to fluid restriction euvolemic or hypervolemic hyponatremia associated with congestive heart failure, SIADH, and cirrhosis.

Toxicity of Tolvaptan

The oral LD50 of tolvaptan in rats and dogs is 2000 mg/kg. Most common adverse reactions ( 5% placebo) are thirst, dry mouth, asthenia, constipation, pollakiuria or polyuria, and hyperglycemia.

RX24 Drugs Disclaimer: before buying a Tolvaptan on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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