Save up -80% on Tolvaptan
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Samsca
|$3,938||9 tablets/15 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Tolvaptan coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Tolvaptan every time. What are you waiting for? Claim your prescription drug card now!
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Tolvaptan volume of distribution
Healthy subjects: 3L/kg; slightly higher in heart failure patients.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tolvaptan
Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Tolvaptan mechanism of action
Tolvaptan is a selective and competitive arginine vasopressin receptor 2 antagonist. Vasopressin acts on the V2 receptors found in the walls of the vasculature and luminal membranes of renal collecting ducts. By blocking V2 receptors in the renal collecting ducts, aquaporins do not insert themselves into the walls thus preventing water absorption. This action ultimately results in an increase in urine volume, decrease urine osmolality, and increase electrolyte-free water clearance to reduce intravascular volume and an increase serum sodium levels. Tolvaptan is especially useful for heart failure patients as they have higher serum levels of vasopressin.
Dosage forms of Tolvaptan
Otsuka Pharmaceutical Co Ltd
Humans and other mammals
Indication of Tolvaptan
Treatment of symptomatic and resistant to fluid restriction euvolemic or hypervolemic hyponatremia associated with congestive heart failure, SIADH, and cirrhosis.
Toxicity of Tolvaptan
The oral LD50 of tolvaptan in rats and dogs is 2000 mg/kg. Most common adverse reactions ( 5% placebo) are thirst, dry mouth, asthenia, constipation, pollakiuria or polyuria, and hyperglycemia.
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