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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tolvaptan

$

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Tolvaptan volume of distribution

Healthy subjects: 3L/kg; slightly higher in heart failure patients.

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What is Tolvaptan

Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.

Tolvaptan mechanism of action

Tolvaptan is a selective and competitive arginine vasopressin receptor 2 antagonist. Vasopressin acts on the V2 receptors found in the walls of the vasculature and luminal membranes of renal collecting ducts. By blocking V2 receptors in the renal collecting ducts, aquaporins do not insert themselves into the walls thus preventing water absorption. This action ultimately results in an increase in urine volume, decrease urine osmolality, and increase electrolyte-free water clearance to reduce intravascular volume and an increase serum sodium levels. Tolvaptan is especially useful for heart failure patients as they have higher serum levels of vasopressin.

Dosage forms of Tolvaptan

FormRouteStrength
Tabletoral
Tabletoral15 mg/1
Tabletoral15 mg
Prescription Generics

false

International Brands

Jinarc

Synonyms

Samsca

Manufacturers

Otsuka Pharmaceutical Co Ltd

CAS number

150683-30-0

UNII

21G72T1950

State

solid

Affected organisms

Humans and other mammals

Indication of Tolvaptan

Treatment of symptomatic and resistant to fluid restriction euvolemic or hypervolemic hyponatremia associated with congestive heart failure, SIADH, and cirrhosis.

Toxicity of Tolvaptan

The oral LD50 of tolvaptan in rats and dogs is 2000 mg/kg. Most common adverse reactions ( 5% placebo) are thirst, dry mouth, asthenia, constipation, pollakiuria or polyuria, and hyperglycemia.

RX24 Drugs Disclaimer: before buying a Tolvaptan on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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