Save up -80% on Topiramate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Qsymia
|$192.54||30 capsules/46 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Topiramate volume of distribution
Topiramate is rapidly absorbed, with a high bioavailability that is not affected by concomitant food intake. The volume of distribution is 0.6-0.8 l/kg, suggesting distribution into total body water.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Topiramate
Topiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved for, and now most frequently prescribed for, the prevention of migraines. (Wikipedia). A combination product containing phentermine and topiramate extended-release called QSYMIA is indicated for the management of obesity. On August 2013, an extended released formulation, marketed as Trokendi XR has been approved for the management of partial onset, tonic-clonic, and Lennox-Gastaut Syndrome seizures.
Topiramate mechanism of action
The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons in a time-dependent manner, suggesting a state-dependent sodium channel blocking action. Topiramate also augments the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABA sub A /sub receptor (controls an integral chloride channel), indicating a possible mechanism through potentiation of the activity of GABA. Topiramate also demonstrates antagonism of the AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (particularly isozymes II and IV), but this action is weak and unlikely to be related to its anticonvulsant actions.
Dosage forms of Topiramate
|Capsule, extended release||oral|
|Capsule, extended release||oral||100 mg/1|
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
Bgp Pharma Ulc
Humans and other mammals
Indication of Topiramate
Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia is indicated for the treatment and management of obesity.
Toxicity of Topiramate
Symptoms of overdose include abdominal pain, agitation, blurred vision, convulsions, depression, dizziness, double vision, drowsiness, impaired coordination, impaired mental activity, low blood pressure, reduced consciousness, severe diarrhea, sluggishness, and speech problems.
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What is Qsymia?
Qsymia contains a combination of phentermine and topiramate in an extended release capsule. Phentermine is an appetite suppressant like amphetamine. Topiramate is a seizure, also called an anticonvulsant. Qsymia is used along with diet and exercise to treat obesity. This medicine is sometimes used to treat obesity, which may be associated with diabetes, high cholesterol, or high blood pressure.
Qsymia will not apply to these basic conditions. Continue to use any other medications prescribed by your doctor to treat these conditions. Do not use Qsymia if you are pregnant. This medicine may cause birth defects.
You should not take Qsymia if you are allergic to phentermine (Adipex-P, Oby-Cap, Suprenza, T-Diet, Zantryl) or topiramate (Topamax), or if you have glaucoma or an overactive thyroid gland. Do not use Qsymia if you have used an MAO inhibitor such as furazolidone (furoxone), isocarboxazid (Marplan), fenelzine (Nardil), rasagiline (Azilect), selegilin (Eldepryl, Emsam, Zelapar) or tranylcypromin (Parnate) in the last 14 days. Dangerous interactions with the drug may occur, with serious side effects.
Before taking Qsymia, tell your doctor if you have high blood pressure, heart disease, diabetes, liver or kidney disease, low potassium in the blood, or if you have had a heart attack or stroke in the last 6 months.
Phentermine can be addictive and should only be used by the person for whom it was prescribed. Keep the medicine in a safe place where others cannot reach it. Do not suddenly stop taking Qsymia, or you may have a seizure (convulsions). You may have to use less and less before you completely stop taking the medicine. Ask your doctor how to avoid seizures when you stop using Qsymia.