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2018 Price of Topiramate
Pms-Topiramate 50 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Topiramate volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Topiramate
Topiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved for, and now most frequently prescribed for, the prevention of migraines. (Wikipedia). A combination product containing phentermine and topiramate extended-release called QSYMIA is indicated for the management of obesity. On August 2013, an extended released formulation, marketed as Trokendi XR has been approved for the management of partial onset, tonic-clonic, and Lennox-Gastaut Syndrome seizures.
Topiramate mechanism of action
The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons in a time-dependent manner, suggesting a state-dependent sodium channel blocking action. Topiramate also augments the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABA sub A /sub receptor (controls an integral chloride channel), indicating a possible mechanism through potentiation of the activity of GABA. Topiramate also demonstrates antagonism of the AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (particularly isozymes II and IV), but this action is weak and unlikely to be related to its anticonvulsant actions.
Dosage forms of Topiramate
|Capsule, extended release||oral|
|Capsule, extended release||oral||100 mg/1|
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
Bgp Pharma Ulc
Humans and other mammals
Indication of Topiramate
Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia is indicated for the treatment and management of obesity.
Toxicity of Topiramate
Symptoms of overdose include abdominal pain, agitation, blurred vision, convulsions, depression, dizziness, double vision, drowsiness, impaired coordination, impaired mental activity, low blood pressure, reduced consciousness, severe diarrhea, sluggishness, and speech problems.
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