Save up -80% on Topotecan

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Topotecan

Hycamtin 0.25 mg capsule

$89.73

capsule

* price without discount in nearest pharmacy. Price may vary.

Claim your free Topotecan discount card

We offer free Topotecan coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Topotecan every time. What are you waiting for? Claim your prescription drug card now!

Get your Prescription
It’s safe and free
Buy drugs in pharmacy
Save money each time

Topotecan volume of distribution

About RX24Drugs

Discount Cards 16,000+

Clients Benefit 29%

Total savings $4,735,080

What is Topotecan

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.

Topotecan mechanism of action

Topotecan has the same mechanism of action as irinotecan and is believed to exert its cytotoxic effects during the S-phase of DNA synthesis. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. This ternary complex interferes with the moving replication fork, which leads to the induction of replication arrest and lethal double-stranded breaks in DNA. As mammalian cells cannot efficiently repair these double strand breaks, the formation of this ternary complex eventually leads to apoptosis (programmed cell death). Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (1) and downstream (+1) base pairs. Intercalation displaces the downstream DNA, thus preventing religation of the cleaved strand. By specifically binding to the enzymesubstrate complex, Topotecan acts as an uncompetitive inhibitor.

Dosage forms of Topotecan

FormRouteStrength
Capsuleoral.25 mg/1
Capsuleoral1 mg/1
Capsule, hardOral use0.25 mg
Prescription Generics

false

International Brands

Act Topotecan

Synonyms

9-((dimethylamino)Methyl)-10-hydroxy-(4S)-camptothecin Topotecane

Manufacturers

Actavis Pharma Company

CAS number

123948-87-8

UNII

7M7YKX2N15

State

solid

Affected organisms

Humans and other mammals

Indication of Topotecan

For the treatment of advanced ovarian cancer in patients with disease that has recurred or progressed following therapy with platinum-based regimens. Also used as a second-line therapy for treatment-sensitive small cell lung cancer, as well as in combination with cisplatin for the treatment of stage IV-B, recurrent, or persistent cervical cancer not amenable to curative treatment with surgery and/or radiation therapy.

Toxicity of Topotecan

The primary anticipated complication of overdosage would consist of bone marrow suppression.

RX24 Drugs Disclaimer: before buying a Topotecan on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

Get lower price on Topotecan now!