Save up -80% on Trabectedin | |||
Note: this is a drug discount program, not an insurance plan. | |||
RX BIN: 015558 | RX PCN: HT | Group ID: DDN6600 | Card Holder ID: DDN6600 |
Pharmacists and Patients support. |
2019 Price of Yondelis | |
$8,615 | 3 vials/1 mg |
price without discount in nearest pharmacy. Price may vary. |
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Trabectedin volume of distribution

About RX24Drugs
2018 Statistics

Discount Cards 16,000+

Clients Benefit 29%

Total savings $4,735,080
What is Trabectedin
Trabectedin, also referred as ET-743 during its development, is a marine derived antitumoral agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery.It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is also undergoing clinical trials for the treatment of breast, prostate, and paediatric sarcomas. The European Commission and the U.S. Food and Drug Administration (FDA) have granted orphan drug status to trabectedin for soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Trabectedin mechanism of action
Trabectedin interacts with the minor groove of DNA and alkylates guanine at the N2 position, which bends towards the major groove. In this manner, it is thought that the drug affects various transcription factors involved in cell proliferation, particularly via the transcription-coupled nucleotide excision repair system. Trabectedin blocks the cell cycle at the G2 phase, while cells at the G1 phase are most sensitive to the drug. It also inhibits overexpression of the multidrug resistance-1 gene (MDR-1) coding for the P-glycoprotein that is a major factor responsible for cells developing resistance to cancer drugs. The agent is also thought to interfere with the nucleotide excision repair pathways of cancer cells, suggesting that it could be effective in the treatment of many cancer types including melanoma and sarcoma, as well as lung, breast, ovarian, endometrial and prostate cancers; clinical evaluations are underway in these indications.
Dosage forms of Trabectedin
Form | Route | Strength |
Injection, powder, lyophilized, for solution | intravenous | .05 mg/mL |
Powder for solution | intravenous | 1 mg |
Prescription Generics
false
International Brands
Yondelis
Synonyms
Ecteinascidin 743
Manufacturers
Janssen Products, LP
CAS number
114899-77-3
UNII
ID0YZQ2TCP
State
solid
Affected organisms
Humans and other mammals
Indication of Trabectedin
Indicated for treatment of advanced soft tissue sarcoma in patients refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy in Europe, Russia and South Korea. Approved for orphan drug status by the U.S. FDA for treatment of soft tissue sarcomas and ovarian cancer. Investigated for use/treatment in cancer/tumors (unspecified), gastric cancer, ovarian cancer, pediatric indications, sarcoma, and solid tumors.
Toxicity of Trabectedin
RX24 Drugs Disclaimer: consult your healthcare provider before buying a Trabectedin on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.