Save up -80% on Tramadol
Note: this is a drug discount program, not an insurance plan.
2018 Price of Tramadol
Tramadol-Acetaminophen 37.5-325 mg tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Tramadol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Tramadol every time. What are you waiting for? Claim your prescription drug card now!
Tramadol volume of distribution
* 2.6 L/kg (male, 100 mg intravenous dose) * 2.9 L/kg (female, 100 mg intravenous dose)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tramadol
A narcotic analgesic proposed for moderate to severe pain. It may be habituating. Tramadol is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form.
Tramadol mechanism of action
Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.
Dosage forms of Tramadol
|Capsule, extended release||oral||100 mg/1|
|Capsule, extended release||oral||200 mg/1|
|Capsule, extended release||oral||300 mg/1|
Actavis Pharma Company
Humans and other mammals
Indication of Tramadol
Indicated in the treatment of moderate to severe pain. Consider for those prone to constipation or respiratory depression. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.
Toxicity of Tramadol
LD sub 50 /sub =350mg/kg (orally in mice)
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