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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tramadol

Tramadol-Acetaminophen 37.5-325 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Tramadol volume of distribution

* 2.6 L/kg (male, 100 mg intravenous dose) * 2.9 L/kg (female, 100 mg intravenous dose)

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What is Tramadol

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. Tramadol is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form.

Tramadol mechanism of action

Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.

Dosage forms of Tramadol

Capsule, extended releaseoral100 mg/1
Capsule, extended releaseoral200 mg/1
Capsule, extended releaseoral300 mg/1
Prescription Generics


International Brands

Act Tramadol/acet


(+)-Tramadol (+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol


Actavis Pharma Company

CAS number






Affected organisms

Humans and other mammals

Indication of Tramadol

Indicated in the treatment of moderate to severe pain. Consider for those prone to constipation or respiratory depression. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis.

Toxicity of Tramadol

LD sub 50 /sub =350mg/kg (orally in mice)

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