Save up -80% on Trametinib

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Mekinist


30 tablets (0.5mg)

* price without discount in nearest pharmacy. Price may vary.

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Trametinib volume of distribution

Apparent volume of distribution (Vd/F) = 214 L

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What is Trametinib

Trametinib dimethyl sulfoxide is a kinase inhibitor. Each 1-mg tablet contains 1.127 mg trametinib dimethyl sulfoxide equivalent to 1 mg of trametinib non-solvated parent. FDA approved on May 29, 2013.

Trametinib mechanism of action

Trametinib is a reversible, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and of MEK1 and MEK2 kinase activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. Trametinib helps with melanoma with the BRAF V600E or V600K as the mutation results in the constitutive activation of the BRAF pathway which includes MEK1 and MEK2.

Dosage forms of Trametinib

Mekinist0.5mg30 tablets$2,626
Mekinist2mg30 tablets$10,209
Prescription Generics


International Brands



GSK 1120212 JTP 74057


Glaxo Smith Kline Llc

CAS number






Affected organisms

Humans and other mammals

Indication of Trametinib

Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test.

Toxicity of Trametinib

Most common adverse reactions ( 20%) for trametinib include rash, diarrhea, and lymphedema.

RX24 Drugs Disclaimer: before buying a Trametinib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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