Save up -80% on Trametinib
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Mekinist
|$3,301.47||30 tablets (0.5mg)|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Trametinib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Trametinib every time. What are you waiting for? Claim your prescription drug card now!
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Trametinib volume of distribution
Trametinib is administered orally. It is highly bound to plasma proteins (97.4%) and has an apparent volume of distribution of 214 liters (L).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Trametinib
Trametinib dimethyl sulfoxide is a kinase inhibitor. Each 1-mg tablet contains 1.127 mg trametinib dimethyl sulfoxide equivalent to 1 mg of trametinib non-solvated parent. FDA approved on May 29, 2013.
Trametinib mechanism of action
Trametinib is a reversible, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and of MEK1 and MEK2 kinase activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. Trametinib helps with melanoma with the BRAF V600E or V600K as the mutation results in the constitutive activation of the BRAF pathway which includes MEK1 and MEK2.
Dosage forms of Trametinib
GSK 1120212 JTP 74057
Glaxo Smith Kline Llc
Humans and other mammals
Indication of Trametinib
Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test.
Toxicity of Trametinib
Most common adverse reactions ( 20%) for trametinib include rash, diarrhea, and lymphedema.
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