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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Trametinib

$

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Trametinib volume of distribution

Apparent volume of distribution (Vd/F) = 214 L

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What is Trametinib

Trametinib dimethyl sulfoxide is a kinase inhibitor. Each 1-mg tablet contains 1.127 mg trametinib dimethyl sulfoxide equivalent to 1 mg of trametinib non-solvated parent. FDA approved on May 29, 2013.

Trametinib mechanism of action

Trametinib is a reversible, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and of MEK1 and MEK2 kinase activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. Trametinib helps with melanoma with the BRAF V600E or V600K as the mutation results in the constitutive activation of the BRAF pathway which includes MEK1 and MEK2.

Dosage forms of Trametinib

FormRouteStrength
Film-coated tabletOral use0.5 mg
Film-coated tabletOral use2 mg
Tabletoral0.5 mg
Prescription Generics

false

International Brands

Mekinist

Synonyms

GSK 1120212 JTP 74057

Manufacturers

Glaxo Smith Kline Llc

CAS number

871700-17-3

UNII

33E86K87QN

State

solid

Affected organisms

Humans and other mammals

Indication of Trametinib

Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test.

Toxicity of Trametinib

Most common adverse reactions ( 20%) for trametinib include rash, diarrhea, and lymphedema.

RX24 Drugs Disclaimer: before buying a Trametinib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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