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Price of Tranexamic Acid
Cyklokapron 500 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Tranexamic Acid volume of distribution
* 9 to 12 L
What is Tranexamic Acid
Antifibrinolytic hemostatic used in severe hemorrhage. (PubChem)
Tranexamic Acid mechanism of action
Tranexamic acid competitively inhibits activation of plasminogen (via binding to the kringle domain), thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII. Tranexamic acid also directly inhibits plasmin activity, but higher doses are required than are needed to reduce plasmin formation.
Dosage forms of Tranexamic Acid
Pharmacia And Upjohn Company Llc
Humans and other mammals
Indication of Tranexamic Acid
For use in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction. It can also be used for excessive bleeding in menstruation, surgery, or trauma cases.
Toxicity of Tranexamic Acid
Oral LD sub 50 /sub in mice is 10 gm/kg. Symptoms of overdosage may be nausea, vomiting, orthostatic symptoms and/or hypotension.
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