Save up -80% on Trastuzumab
Note: this is a drug discount program, not an insurance plan.
Price of Trastuzumab
Herceptin 440 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Trastuzumab volume of distribution
* 44 mL/kg
What is Trastuzumab
A recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein. Produced in CHO cell culture.
Trastuzumab mechanism of action
Trastuzumab binds to the HER2 (or c-erbB2) proto-oncogene, an EGF receptor-like protein found on 20-30% of breast cancer cells. The binding leads to antibody mediated (complement mediated) killing of the HER2 positive cells.
Dosage forms of Trastuzumab
|Powder for concentrate for solution for infusion||Intravenous use||150 mg|
|Powder for solution||intravenous||440 mg|
Ig gamma-1 chain C region
Humans and other mammals
Indication of Trastuzumab
For treatment of early stage HER2-positive breast cancer, or metastatic breast cancer that substantially overexpress HER2.
Toxicity of Trastuzumab
Administration of trastuzumab can result in ventricular dysfunction and congestive heart failure. Risk of cardiotocity is especially elevated in patients recieving concurrent anthracycline or cyclophosphamide therapy.
Disclaimer: before buying a Trastuzumab on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.