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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Desyrel

$6.9930 tablets/50mg
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Trazodone volume of distribution

No differences were observed in the total amount of trazodone absorbed with or without food with bioavailability values of 65 +/- 6 and 63 +/- 4 per cent, respectively. The apparent volume of distribution and total body clearance for trazodone were estimated to 0.84 +/- 0.16 l/kg and 5.3 +/- 0.9 l/hr, respectively.

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Trazodone

A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)

Trazodone mechanism of action

Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone’s antidepressant activity likely results from blockage of serotonin reuptake by inhibiting serotonin reuptake pump at the presynaptic neuronal membrane. If used for long time periods, postsynaptic neuronal receptor binding sites may also be affected. The sedative effect of trazodone is likely the result of alpha-adrenergic blocking action and modest histamine blockade at H1 receptor. It weakly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. Trazodone does not affect the reuptake of norepinephrine or dopamine within the CNS.

Dosage forms of Trazodone

DrugDosageQuantityPrice
Trazodone50mg100 Scored Tablet$38.00
Trazodone100mg100 Scored Tablet$59.00
Trazodone150mg100 Scored Tablet$75.00

Prescription Generics

true

International Brands

Apo-trazodone D Tablets 150mg

Synonyms

2-(3-(4-(3-Chlorophenyl)-1-piperazinyl)propyl)(1,2,4)triazolo(4,3-a)pyridin-3(2H)-one Trazodona

Manufacturers

Apotex Inc

CAS number

19794-93-5

UNII

YBK48BXK30

State

solid

Affected organisms

Humans and other mammals

Indication of Trazodone

For the treatment of depression.

Toxicity of Trazodone

LD sub50 /sub=96mg/kg (i.v. in mice)

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