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Price of Treprostinil
Remodulin 1 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Treprostinil volume of distribution
* 14 L/70 kg
What is Treprostinil
Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension. Treprostinil is marketed as Remodulin reg;. (Wikipedia)
Treprostinil mechanism of action
The major pharmacological actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. In addition to treprostinil’s direct vasodilatory effects, it also inhibits inflammatory cytokine. As a synthetic analogue of prostacyclin, it binds to the prostacyclin receptor, which subsequently induces the aforementioned downstream effects.
Dosage forms of Treprostinil
|Tablet, extended release||oral||.125 mg/1|
|Tablet, extended release||oral||.25 mg/1|
|Tablet, extended release||oral||1 mg/1|
(1R,2R,3aS,9aS)-((2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-((3S)-3-hydroxyoctyl)-1H-benz(f)inden-5-yl) oxy)acetic acid
United Therapeutics Corp.
Humans and other mammals
Indication of Treprostinil
For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Toxicity of Treprostinil
Symptoms of overdose are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of treprostinil.
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