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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Orenitram

$7,712.18180 tablets/1mg
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Treprostinil volume of distribution

Remodulin when administered chronically as a subcutaneous infusion is completely absorbed and has a mean apparent elimination half-life of 3 hours compared to 45 minutes when administered intravenously. The mean volume of distribution and plasma clearance for treprostinil are 1.1 L/kg and 589 mL/kg/hr, respectively.

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2018 Statistics

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Total savings $4,735,080

What is Treprostinil

Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension. Treprostinil is marketed as Remodulin reg;. (Wikipedia)

Treprostinil mechanism of action

The major pharmacological actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. In addition to treprostinil’s direct vasodilatory effects, it also inhibits inflammatory cytokine. As a synthetic analogue of prostacyclin, it binds to the prostacyclin receptor, which subsequently induces the aforementioned downstream effects.

Dosage forms of Treprostinil

Tablet, extended releaseoral.125 mg/1
Tablet, extended releaseoral.25 mg/1
Tablet, extended releaseoral1 mg/1

Prescription Generics


International Brands



(1R,2R,3aS,9aS)-((2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-((3S)-3-hydroxyoctyl)-1H-benz(f)inden-5-yl) oxy)acetic acid (((1R,2R,3aS,9aS)-2-Hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta(b)naphtalen-5-yl)oxy)acetic acid


United Therapeutics Corp.

CAS number






Affected organisms

Humans and other mammals

Indication of Treprostinil

For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.

Toxicity of Treprostinil

Symptoms of overdose are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of treprostinil.

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