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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Atralin

$68.501 tube (45g) 0.025% cream
price without discount in nearest pharmacy. Price may vary.

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Tretinoin volume of distribution

Confidence intervals for binomial parameters were computed using the method of Ghosh. Day 1 and day 15 values for each pharmacokinetic parameter (concentration of tretinoin at the end of the infusion, tenninal-phase half-life [td], area under the curve of [AUC] of tretinoin concentration versus time, clearance of ATRA from blood, and volume of distribution with and without adjustment for body weight) were compared using the Wilcoxon sign-rank test for paired data. Functional relationships between AUC on day 15 (AUC 15) or day 1 (AUCI) and dose were assessed by nonlinear regression, including exploration of various transformations of the variables.

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What is Tretinoin

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).

Tretinoin mechanism of action

Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

Dosage forms of Tretinoin

DrugDosageQuantityPrice
Retisol A0.05%45g Cream$65.00
Retisol A Forte0.10%45g Cream$67.00
Tri-Luma cream0.01/4/0.5%30g Cream$188.00
Biacna Topical Gel1.2/0.025%60g Topical Gel$130.00
Retin-A Gel0.025%30g Gel$42.50
Stieva A Cream0.01%25g Cream$39.00

Prescription Generics

false

International Brands

Atralin

Synonyms

(all-e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ecl)

Manufacturers

Coria Laboratories

CAS number

302-79-4

UNII

5688UTC01R

State

solid

Affected organisms

Humans and other mammals

Indication of Tretinoin

For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier’s disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Toxicity of Tretinoin

After topical treatment, dams receiving 10 mg/kg daily or greater had severe local and systemic toxicity prompting discontinuation of tretinoin. At doses of 2.5 mg/kg or greater, dam weight gain and food consumption were significantly less than those of control dams.

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What is Atralin?

Atralin gel (tretinoin) is a form of vitamin A that helps the skin to be renewed. Atralin Gel 0.05% is used for the topical treatment of acne. It’s also is used to reduce the appearance of fine wrinkles and spotted skin discoloration, as well as for smoother skin.

Avoid exposure to sunlight or artificial UV rays (sunglasses or tanning beds). Atralin can make your skin more sensitive to sunlight and sunburn. Use sunscreen (minimum SPF 15) and wear protective clothing if you must be in the sun. Avoid getting Atralin in the eyes, mouth and nose, or on the lips. If it gets into any of these areas, rinse with water. Do not use Atralin on tanned, windy, dry, cracked, irritated or broken skin. Also avoid using this drug in wounds or on eczema patches. Wait until these conditions have healed before using Atralin.

Use this medication as many days as have been prescribed for you, even if you think it is not working. It may take weeks or months of use before you notice improvement in your skin. If you use Atralin to treat acne, your condition may worsen slightly in a short time when you first start using the medicine. Call your doctor if skin irritation becomes severe or if your acne does not improve within 8-12 weeks.

Follow all directions on label and package. Tell each of your health care providers about all your medical conditions, allergies, and all medications you use.