Save up -80% on Triamcinolone
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Price of Triamcinolone
Oracort 0.1 % Paste
* price without discount in nearest pharmacy. Price may vary.
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Triamcinolone volume of distribution
What is Triamcinolone
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Triamcinolone mechanism of action
The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Dosage forms of Triamcinolone
|Spray, suspension||nasal||55 ug/1|
|Spray, metered||nasal||.5 mg/mL|
24 Hour Nasal Allergy
Humans and other mammals
Indication of Triamcinolone
For the treatment of perennial and seasonal allergic rhinitis.
Toxicity of Triamcinolone
LD sub50 /sub=500mg/kg (in rats)
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