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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Triclosan

$

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Triclosan volume of distribution

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What is Triclosan

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.[ChEBI]

Triclosan mechanism of action

At in-use concentrations, triclosan acts as a biocide, with multiple cytoplasmic and membrane targets. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to bacterial enoyl-acyl carrier protein reductase enzyme (ENR), which is encoded by the gene FabI. This binding increases the enzyme’s affinity for nicotinamide adenine dinucleotide (NAD+). This results in the formation of a stable ternary complex of ENR-NAD+-triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for reproducing and building cell membranes. Humans do not have an ENR enzyme, and thus are not affected.

Dosage forms of Triclosan

FormRouteStrength
Geltopical1.0 %
Solutiontopical11.7 g/100mL
Liquidtopical0.375 %
Prescription Generics

false

International Brands

1% Triclosan Anti-microbial Foaming Skin Cleanser

Synonyms

2,4,4′-Trichloro-2′-hydroxydiphenyl ether 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol

Manufacturers

Deb Canada

CAS number

3380-34-5

UNII

4NM5039Y5X

State

solid

Affected organisms

Fungi, yeast and protozoans

Indication of Triclosan

Triclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers. It is also used in health care settings in surgical scrubs and personnel hand washes.

Toxicity of Triclosan

Oral LD50, Rat: 3700 mg/kg; Dermal LD50, Rabbit: 9300 mg/kg

RX24 Drugs Disclaimer: before buying a Triclosan on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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