Save up -80% on Triclosan
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2018 Price of Triclosan
* price without discount in nearest pharmacy. Price may vary.
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Triclosan volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Triclosan
An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.[ChEBI]
Triclosan mechanism of action
At in-use concentrations, triclosan acts as a biocide, with multiple cytoplasmic and membrane targets. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to bacterial enoyl-acyl carrier protein reductase enzyme (ENR), which is encoded by the gene FabI. This binding increases the enzyme’s affinity for nicotinamide adenine dinucleotide (NAD+). This results in the formation of a stable ternary complex of ENR-NAD+-triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for reproducing and building cell membranes. Humans do not have an ENR enzyme, and thus are not affected.
Dosage forms of Triclosan
1% Triclosan Anti-microbial Foaming Skin Cleanser
2,4,4′-Trichloro-2′-hydroxydiphenyl ether 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol
Fungi, yeast and protozoans
Indication of Triclosan
Triclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers. It is also used in health care settings in surgical scrubs and personnel hand washes.
Toxicity of Triclosan
Oral LD50, Rat: 3700 mg/kg; Dermal LD50, Rabbit: 9300 mg/kg
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