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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Trifluridine

Sandoz Trifluridine 1 % Solution

$3.41

ml

* price without discount in nearest pharmacy. Price may vary.

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Trifluridine volume of distribution

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What is Trifluridine

An antiviral derivative of thymidine used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)

Trifluridine mechanism of action

The mechanism of action of trifluridine has not been fully determined, but appears to involve the inhibition of viral replication. Trifluridine does this by incorporating into viral DNA during replication, which leads to the formation of defective proteins and an increased mutation rate. This drug also reversibly inhibits thymidylate synthetase, an enzyme that is necessary for DNA synthesis.

Dosage forms of Trifluridine

FormRouteStrength
Tablet, film coatedoral
Solutionophthalmic1 %
Solutionophthalmic1 g/100mL
Prescription Generics

true

International Brands

Apo-trifluridine Ophthalmic Solution

Synonyms

5-(Trifluoromethyl)deoxyuridine 5-Trifluoromethyl-2-deoxyuridine

Manufacturers

Apotex Inc

CAS number

70-00-8

UNII

RMW9V5RW38

State

solid

Affected organisms

Human Herpes Virus

Indication of Trifluridine

Ophthalmic solution for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2.

Toxicity of Trifluridine

Overdosage by ocular instillation is unlikely because any excess solution should be quickly expelled from the conjunctival sac. Acute overdosage by accidental oral ingestion has not occurred. However, should such ingestion occur, the 75 mg dosage of trifluridine in a 7.5 mL bottle of trifluridine is not likely to produce adverse effects. Single intravenous doses of 1.5 to 30 mg/kg/day in children and adults with neoplastic disease produce reversible bone marrow depression as the only potentially serious toxic effect and only after three to five courses of therapy. The acute oral LD sub50 /sub in the mouse and rat was 4379 mg/kg or higher.

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