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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Viroptic

$62.511 eye dropper (7.5ml) 1%
Price with discount in nearest pharmacy. Price may vary.

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Trifluridine volume of distribution

Following a single dose of Lonsurf (35 mg/m2) in patients with advanced solid tumours, the apparent volume of distribution (Vd/F) for trifluridine was 21 L.

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What is Trifluridine

An antiviral derivative of thymidine used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)

Trifluridine mechanism of action

The mechanism of action of trifluridine has not been fully determined, but appears to involve the inhibition of viral replication. Trifluridine does this by incorporating into viral DNA during replication, which leads to the formation of defective proteins and an increased mutation rate. This drug also reversibly inhibits thymidylate synthetase, an enzyme that is necessary for DNA synthesis.

Dosage forms of Trifluridine

Tablet, film coatedoral
Solutionophthalmic1 %
Solutionophthalmic1 g/100mL

Prescription Generics


International Brands

Apo-trifluridine Ophthalmic Solution


5-(Trifluoromethyl)deoxyuridine 5-Trifluoromethyl-2-deoxyuridine


Apotex Inc

CAS number






Affected organisms

Human Herpes Virus

Indication of Trifluridine

Ophthalmic solution for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2.

Toxicity of Trifluridine

Overdosage by ocular instillation is unlikely because any excess solution should be quickly expelled from the conjunctival sac. Acute overdosage by accidental oral ingestion has not occurred. However, should such ingestion occur, the 75 mg dosage of trifluridine in a 7.5 mL bottle of trifluridine is not likely to produce adverse effects. Single intravenous doses of 1.5 to 30 mg/kg/day in children and adults with neoplastic disease produce reversible bone marrow depression as the only potentially serious toxic effect and only after three to five courses of therapy. The acute oral LD sub50 /sub in the mouse and rat was 4379 mg/kg or higher.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Trifluridine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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