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Price of Trihexyphenidyl
Apo-Trihex 2 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Trihexyphenidyl volume of distribution
What is Trihexyphenidyl
One of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. (PubChem)
Trihexyphenidyl mechanism of action
Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson’s disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
Dosage forms of Trihexyphenidyl
Aparkane Tab 2mg
Icn Canada Ltd.
Humans and other mammals
Indication of Trihexyphenidyl
Indicated for the treatment of parkinson’s disease and extrapyramidal reactions caused by drugs.
Toxicity of Trihexyphenidyl
Symptoms of overdose include mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. Central consequences are agitation, confusion, and hallucinations. An untreated overdose may be fatal, particular in children. Premortal signs are respiratory depression and cardiac arrest.
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