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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tigan

$55.190 capsules/300 mg
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Trimethobenzamide volume of distribution

Tigecycline had a large volume of distribution (7 to 10 liters/kg), indicating extensive distribution into the tissues. Food increased the maximum tolerated single-dose from 100 to 200 mg, but the duration of infusion did not affect tolerability. Side effects, mainly nausea and vomiting, which are common to the tetracycline class of antimicrobial agents, were seen in these studies.

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2018 Statistics

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What is Trimethobenzamide

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Trimethobenzamide mechanism of action

The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.

Dosage forms of Trimethobenzamide

Injectionintramuscular100 mg/mL
Injection, solutionintramuscular100 mg/mL
Capsuleoral300 mg/1

Prescription Generics


International Brands



N-((4-(2-Dimethylaminoethoxy)phenyl)methyl)-3,4,5-trimethoxybenzamide Trimethobenzamidum


Pfizer Laboratories Div Pfizer Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Trimethobenzamide

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Toxicity of Trimethobenzamide

Oral LD sub50 /sub in mice is 1600 mg/kg.

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