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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Trimethoprim

Sulfamethoxazole-tmp ds tablet

$1.44

tablet

* price without discount in nearest pharmacy. Price may vary.

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Trimethoprim volume of distribution

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What is Trimethoprim

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim resistance has been reported.

Trimethoprim mechanism of action

Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim’s affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydrofolate synthetase (aka dihydropteroate synthetase), an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug combination also reduces the development of resistance that is seen when either drug is used alone.

Dosage forms of Trimethoprim

DrugDosageQuantityPrice
Trimethoprim100mg100 Tablet$49.00
Trimethoprim200mg100 Tablet$72.50
Sulfamethoxazole Trimethoprim800/160mg100 Tablet$41.00
PolytrimnoDose10mL Eye drops$57.00
Prescription Generics

false

International Brands

Apo Sulfatrim DS Tab

Synonyms

2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 5-((3,4,5-Trimethoxyphenyl)methyl)-2,4-pyrimidinediamine

Manufacturers

Apotex Inc

CAS number

738-70-5

UNII

AN164J8Y0X

State

solid

Affected organisms

Gram negative and gram positive bacteria

Indication of Trimethoprim

For the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller’s diarrhea.

Toxicity of Trimethoprim

LD sub50 /sub=4850 (orally in mice)

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