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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ulipristal

$

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Ulipristal volume of distribution

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What is Ulipristal

Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity. Ulipristal is currently recommended as first line therapy for emergency contraception, due to improved efficacy and similar side effect profile as compared to the traditional use of levonorgestrel or the Yuzpe regimen. The exact mechanism of action for ulipristal is still currently debated, though there is evidence that it functions by inhibiting ovulation. A recent systematic review proclaimed that the majority of available evidence demonstrates an inhibitory effect on ovulation rather than a post-fertilization effect on the endometrium, which has been heavily debated due to ethical concerns related to abortion (Rosato et al, 2016).

Ulipristal mechanism of action

The exact mechanism of action has been heavily debated, although recent evidence suggests that ulipristal functions primarily through inhibition of ovulation, via prevention of progestin binding to the progesterone receptor. In the treatment of fibroids, ulipristal exerts a direct action on fibroids reducing their size through inhibition of cell proliferation and induction of apoptosis.

Dosage forms of Ulipristal

FormRouteStrength
Tabletoral30 mg/1
Tabletoral30 mg
TabletOral use30 mg
Prescription Generics

false

International Brands

Ella

Synonyms

Manufacturers

Laboratoire HRA Pharma

CAS number

159811-51-5

UNII

6J5J15Q2X8

State

solid

Affected organisms

Humans and other mammals

Indication of Ulipristal

As the product Ella (available in Canada and the US), ulipristal is indicated for use as emergency contraception after unprotected intercourse or possible contraceptive failure when administered within 120 hours (5 days) after unprotected intercourse or a known or suspected contraceptive failure. As the product Fibristal (available in Canada), ulipristal is indicated for treatment of the signs and symptoms of uterine fibroids in adult women.

Toxicity of Ulipristal

RX24 Drugs Disclaimer: before buying a Ulipristal on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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