Save up -80% on Ulipristal
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Ella
|$39.45||1 tablet/30 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ulipristal coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ulipristal every time. What are you waiting for? Claim your prescription drug card now!
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Ulipristal volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ulipristal
Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity. Ulipristal is currently recommended as first line therapy for emergency contraception, due to improved efficacy and similar side effect profile as compared to the traditional use of levonorgestrel or the Yuzpe regimen. The exact mechanism of action for ulipristal is still currently debated, though there is evidence that it functions by inhibiting ovulation. A recent systematic review proclaimed that the majority of available evidence demonstrates an inhibitory effect on ovulation rather than a post-fertilization effect on the endometrium, which has been heavily debated due to ethical concerns related to abortion (Rosato et al, 2016).
Ulipristal mechanism of action
The exact mechanism of action has been heavily debated, although recent evidence suggests that ulipristal functions primarily through inhibition of ovulation, via prevention of progestin binding to the progesterone receptor. In the treatment of fibroids, ulipristal exerts a direct action on fibroids reducing their size through inhibition of cell proliferation and induction of apoptosis.
Dosage forms of Ulipristal
|Tablet||Oral use||30 mg|
Laboratoire HRA Pharma
Humans and other mammals
Indication of Ulipristal
As the product Ella (available in Canada and the US), ulipristal is indicated for use as emergency contraception after unprotected intercourse or possible contraceptive failure when administered within 120 hours (5 days) after unprotected intercourse or a known or suspected contraceptive failure. As the product Fibristal (available in Canada), ulipristal is indicated for treatment of the signs and symptoms of uterine fibroids in adult women.
Toxicity of Ulipristal
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