Save up -80% on Umeclidinium
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2018 Price of Incruse Ellipta
1 inhaler (30 blisters) 62.5mcg
* price without discount in nearest pharmacy. Price may vary.
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Umeclidinium volume of distribution
Mean volume of distribution was 86 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Umeclidinium
Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). It is available as a once-daily inhalation monotherapy or as a fixed-dose combination product with the long-acting beta2-agonist vilanterol. COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less than 80%. By blocking the M3 muscarinic receptor which is highly expressed in airway smooth muscle of the lungs, umeclidinium inhibits the binding of acetylcholine and thereby opens up the airways by preventing bronchoconstriction. Its use has been shown to provide clinically significant, sustained improvements in lung function.
Umeclidinium mechanism of action
Umeclidinium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through the inhibition of M3 receptor at the smooth muscle leading to bronchodilation.
Dosage forms of Umeclidinium
|Incruse Ellipta||62.5mcg||30doses Powder Inhalation||$90.00|
|Incruse Ellipta||62.5mcg||60doses Powder Inhalation||$167.00|
|Incruse Ellipta||62.5mcg||90doses Powder Inhalation||$242.00|
|Anoro Ellipta||55/22mcg||30doses Dry Powder Inhaler||$120.00|
|Anoro Ellipta||55/22mcg||90doses Dry Powder Inhaler||$346.00|
|Trelegy Ellipta||92/55/22mcg||30 doses Inhalation Powder||$133.00|
|Trelegy Ellipta||92/55/22mcg||90 doses Inhalation Powder||$366.00|
Humans and other mammals
Indication of Umeclidinium
Indicated for the long-term, once-daily, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD).
Toxicity of Umeclidinium
In clinical trials, the most common adverse effects of umeclidinium were nasopharyngitis, upper respiratory tract infection, cough, and arthralgia. Atrial fibrillation occurred in 1% of patients, but was more common among patients treated with umeclidinium than in those treated with placebo. Anticholinergics like umeclidinium should be used with caution in patients with narrow-angle glaucoma and in those with prostatic hyperplasia or bladder-neck obstruction. Inhaled medications can cause paradoxical bronchospasm, which can be fatal.
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