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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Keratol

$13.041 bottle (28.35g) 40% cream
price without discount in nearest pharmacy. Price may vary.

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Urea volume of distribution

FormRouteStrength
Creamtopical39 g/100g
Creamtopical100 mg
Creamtopical
RX Prescription
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About RX24Drugs

2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Urea

Urea 13C is a urea molecule radiolabelled with the non-radioactive element carbon-13. It is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed as Pranactin-Citric) for the detection of Helicobacter pylori infections. H pylori is a common stomach bacteria that has been linked to a variety of upper gastrointestinal disorders such as gastritis, gastric and peptic ulcers, stomach cancer, and gastric mucosa-associated lymphoid-tissue (MALT) lymphoma. The UBT is indicated to confirm H. pylori infection and to monitor post-treatment for its eradication. Radiolabelled urea is available in two forms as 13C and 14C. Both forms can be used within the Urea Breath Test, however some may prefer 13C as it is non-radioactive compared to 14C, which may be preferable in pregnant women and children. The Urea Breath Test is based on the ability of the H. pylori enzyme urease to cleave urea into ammonia and carbon dioxide. As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea cleavage) in the stomach is evidence that H. pylori bacteria are present. To detect H. pylori, urea labeled with 13C is swallowed by the patient. If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 13CO2 is absorbed into the blood and exhaled in the breath. Exhaled breath samples can then be collected and measured for the presence of radioactivity.

Urea mechanism of action

The Urea Breath Test is based on the ability of the H. pylori enzyme urease to cleave urea into ammonia and carbon dioxide. As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea cleavage) in the stomach is evidence that H. pylori bacteria are present. To detect H. pylori, urea labeled with 13C is swallowed by the patient. If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 13CO2 is absorbed into the blood and exhaled in the breath. Exhaled breath samples can then be collected and measured for the presence of radioactivity.

Dosage forms of Urea

DrugDosageQuantityPrice
Urea cream39%227g$119
Urea gel45%28ml$58
Urea lotion40%236.6ml$43
Urea foam35%150G$101
Urea topical emulsion40%28.35g$106
Urealac cream40%28.35g$88
Keratol cream40%28.35g$106

Prescription Generics

false

International Brands

Pranactin-citric

Synonyms

(13C)urea 13C-urea

Manufacturers

Otsuka America Pharmaceutical

CAS number

UNII

W6KX9E6D8X

State

Affected organisms

Indication of Urea

Urea-13C is indicated for use in the qualitative detection of urease associated with Helicobacter pylori in the human stomach and as an aid in the initial diagnosis and post-treatment monitoring of Helicobacter pylori infection in adult patients. The test may be used for monitoring treatment if used at least four (4) weeks following completion of therapy. For these purposes, the system utilizes an Infrared Spectrophotometer for the measurement of the ratio of 13CO2 to 12CO2 in breath samples.

Toxicity of Urea

The clinical symptoms observed in cattle included ataxia, weakness, abdominal pain, dyspnoea, excessive salivation, frothing, violent struggling and bellowing. Acute urea toxicity in cattle may be due to ammonia formed by the rapid breakdown of urea by rumen microorganisms

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