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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Ursodeoxycholic acid

Urso 250 mg Tablet

$1.42tablet
price without discount in nearest pharmacy. Price may vary.

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Ursodeoxycholic acid volume of distribution

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What is Ursodeoxycholic acid

Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.

Ursodeoxycholic acid mechanism of action

Ursodeoxycholic acid reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells. The main mechanism if anticholelithic. Although the exact process of ursodiol’s anticholelithic action is not completely understood, it is thought that the drug is concentrated in bile and decreases biliary cholesterol by suppressing hepatic synthesis and secretion of cholesterol and by inhibiting its intestinal absorption. The reduced cholesterol saturation permits the gradual solubilization of cholesterol from gallstones, resulting in their eventual dissolution.

Dosage forms of Ursodeoxycholic acid

FormRouteStrength
Tabletoral250 mg
Tabletoral500 mg
Capsuleoral300 mg/1

Prescription Generics

false

International Brands

Actigall

Synonyms

(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid (3,5,7)-3,7-dihydroxycholan-24-oic acid

Manufacturers

Actavis Pharma, Inc.

CAS number

128-13-2

UNII

724L30Y2QR

State

solid

Affected organisms

Humans and other mammals

Indication of Ursodeoxycholic acid

The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery.

Toxicity of Ursodeoxycholic acid

Neither accidental nor intentional overdosing with ursodeoxycholic acid has been reported. Doses of ursodeoxycholic acid in the range of 16-20 mg/kg/day have been tolerated for 6-37 months without symptoms by 7 patients. The LD50 for ursodeoxycholic acid in rats is over 5000 mg/kg given over 7-10 days and over 7500 mg/kg for mice. The most likely manifestation of severe overdose with ursodeoxycholic acid would probably be diarrhea, which should be treated symptomatically.

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