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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ustekinumab

$

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Ustekinumab volume of distribution

Plaque psoriasis and psoriatic arthritis dosing: 45mg: ~0.161L/kg 90mg: ~0.179L/kg

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What is Ustekinumab

Ustekinumab, is a human immunosuppressive drug developed by the biotechnology company Centocor. It is a laboratory-manufactured, monoclonal antibody directed against interleukins IL-12 and IL-23. Since 2009, ustekinumab has been approved in US, Canada, and Europe for the treatment of plaque psoriasis and psoriatic arthritis. In September 2016, Janssen announced that the FDA approved the medication for the treatment of moderate-severe Crohn’s disease.

Ustekinumab mechanism of action

Ustekinumab is a human IgG1-kappa monoclonal antibody designed to interfere with the triggering of the body’s inflammatory response through the suppression of certain cytokines. Specifically, ustekinumab blocks interleukin IL-12 and IL-23 by binding with high affinity and specificity to the p40 subunit of IL-12 and IL-23, therefore disrupting the proinflammatory pathway that contributes to several chronic diseases. In a more minor role, ustekinumab also interferes with the expression of monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF- ), interferon-inducible protein-10 (IP-10), and interleukin IL-8.

Dosage forms of Ustekinumab

FormRouteStrength
Injection, solutionsubcutaneous45 mg/.5mL
Injection, solutionsubcutaneous90 mg/mL
Solutionintravenous130 mg/26mL
Prescription Generics

false

International Brands

Stelara

Synonyms

Stelera

Manufacturers

Janssen Inc

CAS number

815610-63-0

UNII

FU77B4U5Z0

State

solid

Affected organisms

Humans and other mammals

Indication of Ustekinumab

Ustekinumab is indicated for management of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy; or is used alone or in conjunction with methotrexate for the management of active psoriatic arthritis in adults. The FDA approved the use of ustekinumab in September 2016 for the treatment of moderate to severe Crohn’s disease. The use of ustekinumab may improve short term clinical response but not clinical remission in moderate to severe Crohn’s disease.

Toxicity of Ustekinumab

RX24 Drugs Disclaimer: before buying a Ustekinumab on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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