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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Valaciclovir

Apo-Valacyclovir (Caplet) 500 mg Tablet



* price without discount in nearest pharmacy. Price may vary.

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Valaciclovir volume of distribution

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What is Valaciclovir

Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex. (Wikipedia)

Valaciclovir mechanism of action

Valaciclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain. When used as a substrate for viral DNA polymerase, acyclovir triphosphate competitively inhibits dATP leading to the formation of ‘faulty’ DNA. This is where acyclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.

Dosage forms of Valaciclovir

Tabletoral1000 mg
Capsuleoral1 g/1
Tablet, film coatedoral1 g/1
Prescription Generics


International Brands



L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester


Apotex Inc

CAS number






Affected organisms

Human Herpes Virus

Indication of Valaciclovir

For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.

Toxicity of Valaciclovir

Adverse effects of overexposure might include headache and nausea.

RX24 Drugs Disclaimer: before buying a Valaciclovir on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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