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Price of Valaciclovir
Apo-Valacyclovir (Caplet) 500 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Valaciclovir volume of distribution
What is Valaciclovir
Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex. (Wikipedia)
Valaciclovir mechanism of action
Valaciclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain. When used as a substrate for viral DNA polymerase, acyclovir triphosphate competitively inhibits dATP leading to the formation of ‘faulty’ DNA. This is where acyclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Dosage forms of Valaciclovir
|Tablet, film coated||oral||1 g/1|
L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine
L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester
Human Herpes Virus
Indication of Valaciclovir
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Toxicity of Valaciclovir
Adverse effects of overexposure might include headache and nausea.
Disclaimer: before buying a Valaciclovir on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.