Save up -80% on Valaciclovir
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Valtrex
|$24.14||30 tablets/1 g|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Valaciclovir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Valaciclovir every time. What are you waiting for? Claim your prescription drug card now!
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Valaciclovir volume of distribution
In a study of immunocompromised pediatric patients, the volume of distribution of a 15 ml/kg dose of valacyclovir was 1.34 ± 0.65 L/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Valaciclovir
Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex. (Wikipedia)
Valaciclovir mechanism of action
Valaciclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain. When used as a substrate for viral DNA polymerase, acyclovir triphosphate competitively inhibits dATP leading to the formation of ‘faulty’ DNA. This is where acyclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Dosage forms of Valaciclovir
|Tablet, film coated||oral||1 g/1|
L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester
Human Herpes Virus
Indication of Valaciclovir
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Toxicity of Valaciclovir
Adverse effects of overexposure might include headache and nausea.
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