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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Valganciclovir

Valcyte 450 mg tablet

$46.99

tablet

* price without discount in nearest pharmacy. Price may vary.

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Valganciclovir volume of distribution

* 0.703 0.134 L/kg

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What is Valganciclovir

Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.

Valganciclovir mechanism of action

Valganciclovir is a prodrug of ganciclovir that exists as a mixture of two diastereomers. After administration, these diastereomers are rapidly converted to ganciclovir by hepatic and intestinal esterases. In cytomegalovirus (CMV)-infected cells, ganciclovir is initially phosphorylated to the monophosphate form by viral protein kinase, then it is further phosphorylated via cellular kinases to produce the triphosphate form. This triphosphate form is slowly metabolized intracellularly. The phosphorylation is dependent upon the viral kinase and occurs preferentially in virus-infected cells. The virustatic activity of ganciclovir is due to the inhibition of viral DNA synthesis by ganciclovir triphosphate. Ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed.

Dosage forms of Valganciclovir

DrugDosageQuantityPrice
Valganciclovir450mg60 Tablet$820.00
Prescription Generics

true

International Brands

Apo-valganciclovir

Synonyms

Cymeval L-valine, ester with ganciclovir

Manufacturers

Apotex Inc

CAS number

175865-60-8

UNII

GCU97FKN3R

State

solid

Affected organisms

Human Herpes Virus

Indication of Valganciclovir

Valganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections.

Toxicity of Valganciclovir

It is expected that an overdose of valganciclovir could also possibly result in increased renal toxicity.

RX24 Drugs Disclaimer: before buying a Valganciclovir on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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