Save up -80% on Valganciclovir
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Valganciclovir
Valcyte 450 mg tablet
|price without discount in nearest pharmacy. Price may vary.|
We offer free Valganciclovir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Valganciclovir every time. What are you waiting for? Claim your prescription drug card now!
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Valganciclovir volume of distribution
* 0.703 0.134 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Valganciclovir
Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Valganciclovir mechanism of action
Valganciclovir is a prodrug of ganciclovir that exists as a mixture of two diastereomers. After administration, these diastereomers are rapidly converted to ganciclovir by hepatic and intestinal esterases. In cytomegalovirus (CMV)-infected cells, ganciclovir is initially phosphorylated to the monophosphate form by viral protein kinase, then it is further phosphorylated via cellular kinases to produce the triphosphate form. This triphosphate form is slowly metabolized intracellularly. The phosphorylation is dependent upon the viral kinase and occurs preferentially in virus-infected cells. The virustatic activity of ganciclovir is due to the inhibition of viral DNA synthesis by ganciclovir triphosphate. Ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed.
Dosage forms of Valganciclovir
Cymeval L-valine, ester with ganciclovir
Human Herpes Virus
Indication of Valganciclovir
Valganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections.
Toxicity of Valganciclovir
It is expected that an overdose of valganciclovir could also possibly result in increased renal toxicity.
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