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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Depakene

$54.2710 capsules/250mg
price without discount in nearest pharmacy. Price may vary.

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Valproic Acid volume of distribution

The bioavailability of valproic acid is complete and independent of the preparation used. The apparent volume of distribution is relatively small (0.1 to 0.4 L/kg), due to high plasma protein binding.

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What is Valproic Acid

Valproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (CAS number: 76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.

Valproic Acid mechanism of action

Valproic Acid dissociates to the valproate ion in the gastrointestinal tract and then binds to and inhibits GABA transaminase. The drug’s anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Valproic Acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is also a histone deacetylase inhibitor. Valproic acid has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. A study published in August 2005 revealed that patients treated with valproic acid in addition to highly active antiretroviral therapy (HAART) showed a 75% reduction in latent HIV infection.

Dosage forms of Valproic Acid

DrugDosageQuantityPrice
Valproic Acid250mg100 Capsule$45.00
Valproic Acid250mg/5mL450mL Syrup$65.00
Depakene Oral Solution250mg/5mL240mL Syrup$55.70
Depakene Oral Solution250mg/5mL480mL Syrup$97.50

Prescription Generics

true

International Brands

Apo-divalproex

Synonyms

2-n-propyl-n-valeric acid 2-propyl-pentanoic acid

Manufacturers

Apotex Inc

CAS number

99-66-1

UNII

614OI1Z5WI

State

solid

Affected organisms

Humans and other mammals

Indication of Valproic Acid

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.

Toxicity of Valproic Acid

Oral, mouse: LD sub 50 /sub = 1098 mg/kg; Oral, rat: LD sub 50 /sub = 670 mg/kg. Symptoms of overdose may include coma, extreme drowsiness, and heart problems. The safety and tolerability of valproate in pediatric patients were shown to be comparable to those in adults.

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