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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Valrubicin

Valstar 40 mg/ml vial

$219.96

ml

* price without discount in nearest pharmacy. Price may vary.

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Valrubicin volume of distribution

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What is Valrubicin

Valrubicin (N-trifluoroacetyladriamycin-14-valerate, Valstar reg;) is a chemotherapy drug used to treat bladder cancer. Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder. (Wikipedia)

Valrubicin mechanism of action

Valrubicin is an anthracycline that affects a variety of inter-related biological functions, most of which involve nucleic acid metabolism. It readily penetrates into cells, where after DNA intercalation, it inhibits the incorporation of nucleosides into nucleic acids, causes extensive chromosomal damage, and arrests cell cycle in G2. Although valrubicin does not bind strongly to DNA, a principal mechanism of its action, mediated by valrubicin metabolites, is interference with the normal DNA breaking-resealing action of DNA topoisomerase II.

Dosage forms of Valrubicin

FormRouteStrength
Solution, concentrateintravesical40 mg/mL
Solutionintravesical40 mg
Prescription Generics

false

International Brands

Valstar

Synonyms

(8S, 10S)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)–L-lyxo-hexopyranosyl)oxy)-5,12-naphthacenedione 8-valerate 2-oxo-2-((2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-((trifluoroacetyl)amino)hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethyl pentanoate

Manufacturers

Endo Pharmaceuticals Solutions Inc.

CAS number

56124-62-0

UNII

2C6NUM6878

State

solid

Affected organisms

Humans and other mammals

Indication of Valrubicin

For the treatment of cancer of the bladder.

Toxicity of Valrubicin

The primary anticipated complications of overdosage associated with intravesical administration would be consistent with irritable bladder symptoms. Myelosuppression is possible if valrubicin is inadvertently administered systemically or if significant systemic exposure occurs following intravesical administration (e.g., in patients with bladder/rupture perforation). The maximum tolerated dose in humans by either intraperitoneal or intravenous administration is 600 mg/m sup 2 /sup .

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