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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Diovan

$15.3230 tablets/160 mg
price without discount in nearest pharmacy. Price may vary.

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Valsartan volume of distribution

Valsartan peak plasma concentration is reached 2 to 4 hours after dosing. Valsartan shows bi-exponential decay kinetics following intravenous administration, with an average elimination half-life of about 6 hours. Absolute bioavailability for Diovan is about 25% (range 10%-35%).

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Valsartan

Valsartan is an angiotensin-receptor blocker (ARB) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Valsartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Valsartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

Valsartan mechanism of action

Valsartan is an ARB that selectively inhibits the binding of angiotensin II to AT1, which is found in many tissues such as vascular smooth muscle and the adrenal glands. This effectively inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure. Valsartan is selective for AT1 and has virtually no affinity for AT2. Inhibition of aldosterone secretion may inhibit sodium and water reabsorption in the kidneys while decreasing potassium excretion. The primary metabolite of valsartan, valeryl 4-hydroxy valsartan, has no pharmacological activity.

Dosage forms of Valsartan

DrugDosageQuantityPrice
Diovan80mg84 Tablet$47.00
Diovan160mg84 Tablet$50.90
Diovan320mg56 Tablet$48.60
Valsartan40mg100 Tablet$42.00
Valsartan/Hctz320/25mg100 Tablet$39.80
Valsartan/Hctz320/12.5mg30 Tablet$25.30
Diovan HCTZ320/25mg84 Tablet$48.00
Diovan HCTZ160/12.5mg84 Tablet$44.75
Exforge5/160mg84 film coated tablet$138.00
Exforge10/320mg84 film coated tablet$172.75
Exforge HCT5/160/12.5mg84 Tablet$192.00
Entresto97/103mg60 Tablet$285.00

Prescription Generics

false

International Brands

Act Valsartan

Synonyms

(S)-N-Valeryl-N-{(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)-methyl}-valine Diovan

Manufacturers

Actavis Pharma Company

CAS number

137862-53-4

UNII

80M03YXJ7I

State

solid

Affected organisms

Humans and other mammals

Indication of Valsartan

May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.

Toxicity of Valsartan

The most likely manifestations of overdosage include hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. Depressed levels of consciousness, circulatory collapse and shock have been reported. The use of valsartan during pregnancy is contraindicated. While use during the first trimester does not suggest a risk of major anomalies, use during the second and third trimester may cause teratogenicity and severe fetal and neonatal toxicity. Fetal toxic effects may include anuria, oligohydramnios, fetal hypocalvaria, intrauterine growth restriction, prematurity, and patent ductus arteriosus. Anuria-associated anhydramnios/oligohydramnios may produce fetal limb contractures, craniofacial deformation, and pulmonary hypoplasia. Severe anuria and hypotension, resistant to both pressor agents and volume expansion, may occur in the newborn following in utero exposure to valsartan.

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