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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vancocin

$132.6640 capsules/125 mg
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Vancomycin volume of distribution

In patients with normal creatinine clearance, vancomycin has an α-distribution phase of ∼30 min to 1 h and a β-elimination half-life of 6–12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein has been reported in the literature to range from 10% to 50%.

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What is Vancomycin

Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.

Vancomycin mechanism of action

The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls. The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Normally this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents the incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix. In addition, vancomycin alters bacterial-cell-membrane permeability and RNA synthesis. There is no cross-resistance between vancomycin and other antibiotics. Vancomycin is not active in vitro against gram-negative bacilli, mycobacteria, or fungi.

Dosage forms of Vancomycin

FormRouteStrength
Capsuleoral125 mg
Capsuleoral250 mg
Powder for solutionintravenous1.0 g

Prescription Generics

false

International Brands

Jamp-vancomycin

Synonyms

(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-(2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-((N-methyl-D-leucyl)amino)-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo(26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39))pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid (2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo(N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{(2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine)

Manufacturers

Jamp Pharma Corporation

CAS number

1404-90-6

UNII

6Q205EH1VU

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Vancomycin

For the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci.

Toxicity of Vancomycin

The oral LD sub50 /sub in mice is 5000 mg/kg. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice.

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