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Price of Vardenafil
Levitra 2.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Vardenafil volume of distribution
* 208 L
What is Vardenafil
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.
Vardenafil mechanism of action
Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.
Dosage forms of Vardenafil
|Film-coated tablet||Oral use||10 mg|
|Film-coated tablet||Oral use||20 mg|
|Film-coated tablet||Oral use||5 mg|
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Humans and other mammals
Indication of Vardenafil
Used for the treatment of erectile dysfunction
Toxicity of Vardenafil
Symptoms of overdose include vision changes and back and muscle pain.
Disclaimer: before buying a Vardenafil on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.