Save up -80% on Vasopressin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Noctiva
|$431.86||1 nasal spray (3.8g) 0.83mcg/0.1ml|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Vasopressin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Vasopressin every time. What are you waiting for? Claim your prescription drug card now!
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Vasopressin volume of distribution
Exogenous vasopressin (8 arginine vasopressin) is presented as sterile aqueous solution of synthetic vasopressin for intravenous, intramuscular and subcutaneous administration. It is not protein-bound and has a volume of distribution of 140 ml/kg. The plasma half-life of vasopressin is 24 minute. It is cleared by renal elimination (65%) and metabolism (35%) by tissue peptidase.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Vasopressin
Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
Vasopressin mechanism of action
Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Dosage forms of Vasopressin
|Liquid||intramuscular; subcutaneous||10 unit|
|Liquid||intramuscular; subcutaneous||20 unit|
8-Arginine vasopressin 8-L-arginine vasopressin
Humans and other mammals
Indication of Vasopressin
For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Toxicity of Vasopressin
In this β-blocker toxicity model, there were no differences in the survival curves between vasopressin- and glucagon-treated pigs during a 4-hour analysis period. No overall differences were noted in MAP, systolic BP, CO, HR, pH, or glucose levels, although vasopressin treatment yielded higher MAP and systolic BP early in resuscitation.
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