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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zelboraf

$5,158112 tablets/240 mg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Vemurafenib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Vemurafenib every time. What are you waiting for? Claim your prescription drug card now!

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Vemurafenib volume of distribution

The estimation of the volume of distribution for Vemurafenib is 106 L.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Vemurafenib

Vemurafenib is a BRAF enzyme inhibitor developed by Plexxikon and Genentech for the treatment of late-stage melanoma.[Wikipedia]The cobas 4800 BRAF B600 mutation test provided by Roche Molecular Systems is the diagnostic test to confirm eligibility for treatment. FDA approved on August 17, 2011 under the company Hoffmann La Roche.

Vemurafenib mechanism of action

Vemurafenib is an orally available inhibitor of mutated BRAF-serine-threonine kinase. It is especially potent against the BRAF V600E mutation. This mutation involves the substitution of glutamic acid for valine at codon 600. The BRAF oncogene, most of which have the V600E mutation, activates mitogen-activated kinase (MAPK) pathway which results in cell growth, proliferation, and metastasis. Vemurafenib blocks these downstream processes to inhibit tumour growth and eventually trigger apoptosis. Vemurafenib does not have antitumour effects against melanoma cell lines with the wild-type BRAF mutation.

Dosage forms of Vemurafenib

Film-coated tabletOral use240 mg
Tabletoral240 mg
Tablet, film coatedoral240 mg/1

Prescription Generics


International Brands



BRAF(V600E) Kinase Inhibitor RO5185426 PLX4032


Hoffmann La Roche Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Vemurafenib

Treatment of unresectable or metastatic melanoma in patients with the BRAF-V600 mutation.

Toxicity of Vemurafenib

The most common AEs of all severity grades were rash (49%), arthralgia (39%), fatigue (34%), photosensitivity (31%), alopecia (26%) and nausea (19%). Forty-six percent of patients experienced grade 3 or 4 AEs, which were most commonly cutaneous SCC (12%), rash (5%), liver function abnormalities (5%), arthralgia (3%) and fatigue (3%).

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