Save up -80% on Venlafaxine
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2018 Price of Venlafaxine
Effexor Xr 37.5 mg Extended-Release Capsule
* price without discount in nearest pharmacy. Price may vary.
We offer free Venlafaxine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Venlafaxine every time. What are you waiting for? Claim your prescription drug card now!
Venlafaxine volume of distribution
* 7.5 3.7 L/kg (venlafaxine) * 5.7 1.8 L/kg (O-desmethylvenlafaxine(active metabolite))
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Venlafaxine
Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. (Wikipedia)
Venlafaxine mechanism of action
The exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotransmitter activity in the CNS. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors.
Dosage forms of Venlafaxine
|Venlafaxine Xr||37.5mg||100 Capsule||$68.00|
|Venlafaxine Xr||75mg||84 Capsule||$91.00|
|Venlafaxine Xr||150mg||28 Capsule||$32.00|
|Effexor XR||37.5mg||224 Capsule||$107.50|
|Effexor XR||75mg||84 ER Capsule||$64.30|
|Effexor XR||150mg||112 ER Capsule||$176.20|
|Desvenlafaxine||50mg||100 Extended Release Tablet||$44.90|
|Desvenlafaxine||100mg||100 Extended Release Tablet||$67.30|
|Pristiq||50mg||28 Extended Release Tablet||$80.9|
|Pristiq||100mg||84 Extended Release Tablet||$188.50|
Act Venlafaxine XR
Actavis Pharma Company
Humans and other mammals
Indication of Venlafaxine
For the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain.
Toxicity of Venlafaxine
Most patients overdosing with venlafaxine develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Venlafaxine’s toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.
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