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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Vigabatrin

Sabril 500 mg tablet

$16.66

tablet

* price without discount in nearest pharmacy. Price may vary.

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Vigabatrin volume of distribution

1.1 L/kg

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What is Vigabatrin

An analogue of gamma-aminobutyric acid, vigabatrin is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid. (From Martindale The Extra Pharmacopoeia, 31st ed). Off-label uses include treatment of cocaine dependence.

Vigabatrin mechanism of action

Vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase, GABA-T). Duration of action is determined by rate of GABA-T re-synthesis. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Although administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active.

Dosage forms of Vigabatrin

FormRouteStrength
Powderoral500 mg
Powder, for solutionoral50 mg/mL
Tabletoral500 mg
Prescription Generics

false

International Brands

Sabril

Synonyms

4-Amino-5-hexenoic acid Gamma vinyl GABA

Manufacturers

Lundbeck LLC

CAS number

68506-86-5

UNII

GR120KRT6K

State

solid

Affected organisms

Humans and other mammals

Indication of Vigabatrin

For use as an adjunct in treatment resistant epilepsy, refractory complex partial seizures, and secondary generalized seizures. It is also used as monotherapy in infantile spasms in West syndrome.

Toxicity of Vigabatrin

LD50, oral, rat: 3000 mg/kg; Visual field defects may occur following cumulative doses in excess of 2 kg.

RX24 Drugs Disclaimer: before buying a Vigabatrin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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