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Price of Vinblastine
Vinblastine sulf 10 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Vinblastine volume of distribution
What is Vinblastine
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Vinblastine mechanism of action
The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
Dosage forms of Vinblastine
|Powder for solution||intravenous||10 mg|
Eli Lilly Canada Inc
Humans and other mammals
Indication of Vinblastine
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin’s and non-Hodgkin’s lymphomas, mycosis fungoides, histiocytosis, and Kaposi’s sarcoma.
Toxicity of Vinblastine
Oral, mouse: LD sub50 /sub = 423 mg/kg; Oral, rat: LD sub50 /sub = 305 mg/kg.
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