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Price of Vincristine
Vincristine 2 mg/2 ml vial
* price without discount in nearest pharmacy. Price may vary.
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Vincristine volume of distribution
Within 15 to 30 minutes after injection, over 90% of the drug is distributed from the blood into tissue, where it remains tightly, but not irreversibly, bound.
What is Vincristine
Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin’s disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bonemarrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Vincristine mechanism of action
The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca sup2+ /sup-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.
Dosage forms of Vincristine
|Injection, solution||intravenous||1 mg/mL|
Talon Therapeutics, Inc.
Humans and other mammals
Indication of Vincristine
Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms’ tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Toxicity of Vincristine
IVN-RAT LD sub50 /sub 1300 mg/kg; IPR-MUS LD sub50 /sub 5.2 mg/kg. Marqibo must only be administered IV because it is fatal if administered by other routes. Marqibo also has different dosing than vincristine sulphate injection, so attention is needed to prevent overdoses. The most clinically significant adverse effect of vincristine is neurotoxicity.
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