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Price of Vinorelbine
Vinorelbine 50 mg/5 ml vial
* price without discount in nearest pharmacy. Price may vary.
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Vinorelbine volume of distribution
* 25.4 to 40.1 L/kg
What is Vinorelbine
Vinorelbine (Navelbine reg;) is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. (Wikipedia)
Vinorelbine mechanism of action
The antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Like other vinca alkaloids, vinorelbine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca sup 2+ /sup -transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.
Dosage forms of Vinorelbine
|Injection, solution, concentrate||intravenous||10 mg/mL|
|Injection, solution, concentrate||intravenous||50 mg/5mL|
Agila Jamp Canada Inc
Humans and other mammals
Indication of Vinorelbine
For the treatment of non-small-cell lung carcinoma.
Toxicity of Vinorelbine
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