Save up -80% on Vinorelbine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Navelbine
|$70.6||2 vials (5ml)/50 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Vinorelbine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Vinorelbine every time. What are you waiting for? Claim your prescription drug card now!
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Vinorelbine volume of distribution
* 25.4 to 40.1 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Vinorelbine
Vinorelbine (Navelbine reg;) is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. (Wikipedia)
Vinorelbine mechanism of action
The antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Like other vinca alkaloids, vinorelbine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca sup 2+ /sup -transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.
Dosage forms of Vinorelbine
|Injection, solution, concentrate||intravenous||10 mg/mL|
|Injection, solution, concentrate||intravenous||50 mg/5mL|
Agila Jamp Canada Inc
Humans and other mammals
Indication of Vinorelbine
For the treatment of non-small-cell lung carcinoma.
Toxicity of Vinorelbine
In humans, vinorelbine may cause peripheral neuropathy or constipation. In dogs, neutropenia is the dose-limiting toxicity; neurotoxicity appears to be very limited. As are all vinca alkaloids, vinorelbine is a vesicant and therefore must be administered through a carefully placed indwelling catheter.
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